24h emergency switchboard: +41 (0) 91 805 31 11 info@cardiocentro.org
Patient care

Inside this area you will find all the useful information that aims to make your stay at Cardiocentro more comfortable.

Specialties

With the synergy of cardiologists, cardiac surgeons and cardioestestists, the Cardio Center can offers less invasive surgical techniques and the most up-to-date intervention procedures.

Cardiocentro

Managed by a no-profit foundation integrated into the cantonal healthcare service, Cardiocentro Ticino is a state-of-the-art, highly specialized university clinic in Cardiology, Cardiac Surgery and Cardioestesthesia

Laboratory for Cardiovascular Theranostics

Laboratory for Cardiovascular Theranostics

TEAM
Lucio Barile
PD Lucio Barile, PharmD, PhD
Principal Investigator
ORCID

 

Edoardo Lazzarini
Edoardo Lazzarini, PhD
PostDoc
ORCID

 

Vanessa Biemmi
Vanessa Biemmi
PhD Student
ORCID

 

Alessandra Maria Lodrini
Alessandra Maria Lodrini
Visiting PhD Student
ORCID

 

Sara Bolis
Sara Bolis
Lab Technician
ORCID

 

Federico Buccino
Federico Buccino
Master Thesis Student- Erasmus Programme – University of Milano-Bicocca

 

Matteo Ciccaldo
Matteo Ciccaldo
Master Thesis Student- Erasmus Programme – University of Milano-Bicocca

 

Nicole Pietrogiovanna
Nicole Pietrogiovanna
Master Thesis Student, University of Bern, Faculty of Medicine

 

Projects:

Role of Cellular Senescence in Myocardial Infarction.

Following myocardial infarction (MI) senescent cells accumulate into cardiac tissue. They contribute to MI-associated dysfunction via pro-oxidant phenotype and secretion of senescent-associated proteins (SASP). MI activate aging pathways in the heart that are distinct from canonical senescent profile, resulting in a stress-sensitive cardiomyocytes, also in ischemia remote zone, promoting apoptosis. Novel or combination anti-aging approaches may be required to improve outcomes in MI patients. Although much is known about apoptosis following MI in young animals, little is known about the aging-induced apoptotic pathways in the heart after MI.

Exosomes

Extracellular Vesicles as Therapeutic Target for Cardioprotective Approach.

Extracellular vesicles are important cellular effectors that can mediate different effects. Both the cellular target and the molecular content of exosomes depend on the producer cell. Understanding the nature of vesicles and the mechanisms through which they act may lead to develop new strategies to treat heart disease.

Extracellular Vesicles as Biomarkers

Secreted extracellular vesicles (EV) such as exosomes and microvesicles, are prominent and universal form of intercellular communication process. All cells in the organism secrete EV, which are taken up by surrounding cells or circulate in the blood and eventually are taken up by cells at a distance. EV transport and deliver bioactive molecules such as proteins and nucleic acids, which activate intracellular signalling pathways and regulate functions of recipient cells by exerting autocrine, paracrine, and endocrine effects. EV released by cells into the circulation and body fluids display different RNA and protein contents in healthy subjects and patients with different diseases, which can be measured as potential biomarkers of disease. We have number of ongoing studies to evaluate the diagnostic performance of EV surface proteins as biomarkers in various disease conditions, including cancer, degenerative neurological and cardiovascular diseases.

Partnership

Università della Svizzera Italiana
Istituto di Scienze della Vita della Scuola Superiore Sant’Anna di Pisa

Current Fundings


EXosomes based Combination Therapy to target multiple signaling within
cardioprotective pathways

 


VELUX STIFTUNG Science-Funding Foundation
Cardiac exosomes for myocardial senescence repair

 


Effects of epigenetic memory on differentiation and function of iPS-derived
cardiomyocytes generated from somatic cell sources of cardiac versus noncardiac origins.

 


EUROPEAN COMMISSION – Horizon 2020 – Research and Innovation Framework Programme
Evolving reversible iMmunocapture by membrane sensing peptides: towARds scalable extracellular VEsicLes isolation – MARVEL
Granted amount (total): EUR 1’881’104

Website

Collaboration of departments: Laboratory for Cardiovascular Theranostics and Lugano Cell Factory

Consortium
Consiglio Nazionale delle Ricerche – Italy
Fondazione Cardiocentro Ticino – Switzerland
Università Vita-Salute San Raffaele – Italy
Hansabiomed Life Sciences OU – Estonia
Paperdrop Diagnostics – Spain
Amires Sro – Czech Republic

Network

Internal:

  • Laboratory of Cellular and Molecular Cardiology
  • Laboratory for Biomedical Neurosciences
  • GMP Facility
  • Biomedical Technologies
  • Departments of Cardiology and Heart Surgery

External:

 

ESC 2018
ESC 2018 – Moderated Posters Awards – Premiata la ricerca del Cardiocentro

A CCT research in the European scientific network against heart attack – The Swiss National Fund has selected a research project bearing the signature of Dr. Lucio Barile of the Laboratory for Cardiovascular Theranostics – Cardiocentro Ticino. A total of around CHF 300,000 has been allocated to the project.

Cardiocentro Ticino

Via Tesserete 48
CH-6900 Lugano
info@cardiocentro.org

Information and contacts

Laboratory manager

PD Dr. Lucio Barile

Contact

USI contact page

 

Publications

 

Prof. Dr. Stefanos Demertzis
Head of Cardiac Surgery Cardiac Surgery

Scientific Director