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All’interno di quest’area troverà tutte le informazioni utili che hanno lo scopo di rendere più confortevole il suo soggiorno all’Istituto Cardiocentro Ticino.

In Evidenza

Grazie alla sinergia di cardiologi, cardiochirurghi e cardioanestesisti, l’Istituto Cardiocentro Ticino mette a disposizione tecniche chirurgiche sempre meno invasive e le più aggiornate procedure interventistiche.


L’Istituto Cardiocentro Ticino si è da sempre dedicato con impegno alla ricerca e all’innovazione

Area news

In quest’area troverà tutte le notizie e le informazioni relative alle iniziative promosse dal Cardiocentro.


In questa sezione troverà tutti i servizi, le informazioni e i contenuti dedicati ai professionisti.

Laboratory for Cardiovascular Theranostics

Istituto Cardiocentro Ticino has always been deeply committed to research and innovation

Laboratory for Cardiovascular Theranostics

Lucio Barile
Prof. Lucio Barile
Principal Investigator


Edoardo Lazzarini
Edoardo Lazzarini
Post Doc_Lab Coordinator and Project Leader


Claudia Altomare
Claudia Altomare
Senior Research Scientist _Cellular Electrophysiology


Stefano Panella
Stefano Panella
Research Assistant _Flow Cytometer


Ilaria Barison
Ilaria Barison


Giorgia Senesi
Giorgia Senesi


Cristi Gjergji
Cristi Gjergji
Master thesis student



Role of Cellular Senescence in Myocardial Infarction.

Following myocardial infarction (MI) senescent cells accumulate into cardiac tissue. They contribute to MI-associated dysfunction via pro-oxidant phenotype and secretion of senescent-associated proteins (SASP). MI activate aging pathways in the heart that are distinct from canonical senescent profile, resulting in a stress-sensitive cardiomyocytes, also in ischemia remote zone, promoting apoptosis. Novel or combination anti-aging approaches may be required to improve outcomes in MI patients. Although much is known about apoptosis following MI in young animals, little is known about the aging-induced apoptotic pathways in the heart after MI.


Extracellular Vesicles as Therapeutic Target for Cardioprotective Approach.

Extracellular vesicles are important cellular effectors that can mediate different effects. Both the cellular target and the molecular content of exosomes depend on the producer cell. Understanding the nature of vesicles and the mechanisms through which they act may lead to develop new strategies to treat heart disease.

Extracellular Vesicles as Biomarkers

Secreted extracellular vesicles (EV) such as exosomes and microvesicles, are prominent and universal form of intercellular communication process. All cells in the organism secrete EV, which are taken up by surrounding cells or circulate in the blood and eventually are taken up by cells at a distance. EV transport and deliver bioactive molecules such as proteins and nucleic acids, which activate intracellular signalling pathways and regulate functions of recipient cells by exerting autocrine, paracrine, and endocrine effects. EV released by cells into the circulation and body fluids display different RNA and protein contents in healthy subjects and patients with different diseases, which can be measured as potential biomarkers of disease. We have number of ongoing studies to evaluate the diagnostic performance of EV surface proteins as biomarkers in various disease conditions, including cancer, degenerative neurological and cardiovascular diseases.



Università della Svizzera Italiana
Istituto di Scienze della Vita della Scuola Superiore Sant’Anna di Pisa

Current Fundings


Swiss National Science Foundation – SINERGIA-SNF
GRANT_NUMBER: CRSII5_202302 Targeting cellular senescence in physiological, pathological and iatrogenic conditions

Swiss National Science Foundation – SNF
GRANT_NUMBER: IZCOZ0_18294 EXaCT: EXosomes based Combination Therapy to target multiple signaling within cardioprotective pathways

EUROPEAN COMMISSION – Horizon 2020 – Research and Innovation Framework Programme
Evolving reversible iMmunocapture by membrane sensing peptides: towARds scalable extracellular VEsicLes isolation – MARVEL
Granted amount (total): EUR 1’881’104


Collaboration of departments: Laboratory for Cardiovascular Theranostics and Lugano Cell Factory
Consiglio Nazionale delle Ricerche – Italy, Istituto Cardiocentro Ticino – Switzerland, Università Vita-Salute San Raffaele – Italy, Hansabiomed Life Sciences OU – Estonia, Paperdrop Diagnostics – Spain, Amires Sro – Czech Republic.

VELUX STIFTUNG Science-Funding Foundation
Cardiac exosomes for myocardial senescence repair


Effects of epigenetic memory on differentiation and function of iPS-derived
cardiomyocytes generated from somatic cell sources of cardiac versus noncardiac origins.


FONDAZIONE LEONARDO (Lugano, Switzerland)
Exploring mechanism beyond susceptibility of senescent cardiomyocytes to SARS-CoV-2.




Retreat with Cardiovascular Sciences PhD Students from USI Università della Svizzera italiana, Universität Bern and University of Lausanne. 18/11/23


Azucena Rendón-Ángel received the award to the Best Oral Presentation on Translational Research during the 12a Giornata della Ricerca at USI Università della Svizzera italiana. 08/09/23


Azucena Rendón-Ángel – Happy to be presenting our work during the PhD Day at @USI_university – link Twitter


10-11 October 2022, EVengers met for the two-day MARVEL M24 meeting hosted by AMIRES in Prague, Czech Republic
link Linkedin

The Laboratory for Cardiovascular Theranostics and Lugano Cell Factory (Istituto Cardiocentro Ticino_EOC) joint the 1-year meeting for the EU-project MARVEL that will introduce a breakthrough in current Extracellular Vesicles (EVs) isolation standards. 1-Year after the start of the project we finally had our first in-person meeting.

First meeting regarding our SINERGIA project at EPFL Lausanne

EBiomedicine entrusted an internationally recognized scientists and professor in immunology at University of Pittsburgh Prof. Theresa L. Whiteside to write a commentary on our paper on extracellular vesicles and SARS-CoV-2

Our paper on Exosomes and Cardioprotection published on Cardiovascular Research has been voted by senior Editorial Team of the CVR for the “Best Basic Research Paper Award 2018” during the European Society of Cardiology scientific meeting held in Paris in 2019

A CCT research in the European scientific network against heart attack – The Swiss National Fund has selected a research project bearing the signature of Dr. Lucio Barile of the Laboratory for Cardiovascular Theranostics – Istituto Cardiocentro Ticino. A total of around CHF 300,000 has been allocated to the project.



ESC 2018
ESC 2018 – Moderated Posters Awards – Premiata la ricerca del Cardiocentro

Istituto Cardiocentro Ticino

Via Tesserete 48
CH-6900 Lugano

Information and contacts

Laboratory manager

Prof. Lucio Barile, PharmD, PhD


USI contact page




Prof. Dr. med. Stefanos Demertzis
Primario Cardiochirurgia

Direttore Scientifico