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All’interno di quest’area troverà tutte le informazioni utili che hanno lo scopo di rendere più confortevole il suo soggiorno all’Istituto Cardiocentro Ticino.

In Evidenza

Grazie alla sinergia di cardiologi, cardiochirurghi e cardioanestesisti, l’Istituto Cardiocentro Ticino mette a disposizione tecniche chirurgiche sempre meno invasive e le più aggiornate procedure interventistiche.


L’Istituto Cardiocentro Ticino si è da sempre dedicato con impegno alla ricerca e all’innovazione

Area news

In quest’area troverà tutte le notizie e le informazioni relative alle iniziative promosse dal Cardiocentro.


Laboratory for Cardiovascular Theranostics

Istituto Cardiocentro Ticino has always been deeply committed to research and innovation

Laboratory for Cardiovascular Theranostics

Lucio Barile
PD Lucio Barile, PharmD, PhD
Principal Investigator


Edoardo Lazzarini
Edoardo Lazzarini, PhD


Sara Bolis
Sara Bolis
Lab Technician


Stefano Panella
Stefano Panella
Research assistant


Jacopo Burrello
Jacopo Burrello
Visiting PhD Student


Federico Buccino
Federico Buccino
Master Thesis Student- Erasmus Programme – University of Milano-Bicocca


Matteo Ciccaldo
Matteo Ciccaldo
Master Thesis Student- Erasmus Programme – University of Milano-Bicocca



Role of Cellular Senescence in Myocardial Infarction.

Following myocardial infarction (MI) senescent cells accumulate into cardiac tissue. They contribute to MI-associated dysfunction via pro-oxidant phenotype and secretion of senescent-associated proteins (SASP). MI activate aging pathways in the heart that are distinct from canonical senescent profile, resulting in a stress-sensitive cardiomyocytes, also in ischemia remote zone, promoting apoptosis. Novel or combination anti-aging approaches may be required to improve outcomes in MI patients. Although much is known about apoptosis following MI in young animals, little is known about the aging-induced apoptotic pathways in the heart after MI.


Extracellular Vesicles as Therapeutic Target for Cardioprotective Approach.

Extracellular vesicles are important cellular effectors that can mediate different effects. Both the cellular target and the molecular content of exosomes depend on the producer cell. Understanding the nature of vesicles and the mechanisms through which they act may lead to develop new strategies to treat heart disease.

Extracellular Vesicles as Biomarkers

Secreted extracellular vesicles (EV) such as exosomes and microvesicles, are prominent and universal form of intercellular communication process. All cells in the organism secrete EV, which are taken up by surrounding cells or circulate in the blood and eventually are taken up by cells at a distance. EV transport and deliver bioactive molecules such as proteins and nucleic acids, which activate intracellular signalling pathways and regulate functions of recipient cells by exerting autocrine, paracrine, and endocrine effects. EV released by cells into the circulation and body fluids display different RNA and protein contents in healthy subjects and patients with different diseases, which can be measured as potential biomarkers of disease. We have number of ongoing studies to evaluate the diagnostic performance of EV surface proteins as biomarkers in various disease conditions, including cancer, degenerative neurological and cardiovascular diseases.


Università della Svizzera Italiana
Istituto di Scienze della Vita della Scuola Superiore Sant’Anna di Pisa

Current Fundings

EXosomes based Combination Therapy to target multiple signaling within
cardioprotective pathways


VELUX STIFTUNG Science-Funding Foundation
Cardiac exosomes for myocardial senescence repair


Effects of epigenetic memory on differentiation and function of iPS-derived
cardiomyocytes generated from somatic cell sources of cardiac versus noncardiac origins.



EUROPEAN COMMISSION – Horizon 2020 – Research and Innovation Framework Programme
Evolving reversible iMmunocapture by membrane sensing peptides: towARds scalable extracellular VEsicLes isolation – MARVEL
Granted amount (total): EUR 1’881’104


Collaboration of departments: Laboratory for Cardiovascular Theranostics and Lugano Cell Factory

Consiglio Nazionale delle Ricerche – Italy
Istituto Cardiocentro Ticino – Switzerland
Università Vita-Salute San Raffaele – Italy
Hansabiomed Life Sciences OU – Estonia
Paperdrop Diagnostics – Spain
Amires Sro – Czech Republic




ESC 2018
ESC 2018 – Moderated Posters Awards – Premiata la ricerca del Cardiocentro

A CCT research in the European scientific network against heart attack – The Swiss National Fund has selected a research project bearing the signature of Dr. Lucio Barile of the Laboratory for Cardiovascular Theranostics – Istituto Cardiocentro Ticino. A total of around CHF 300,000 has been allocated to the project.

Istituto Cardiocentro Ticino

Via Tesserete 48
CH-6900 Lugano

Information and contacts

Laboratory manager

PD Dr. Lucio Barile


USI contact page




Prof. Dr. med. Stefanos Demertzis
Primario Cardiochirurgia

Direttore Scientifico